Opioid activity is because of both of those lower affinity binding with the parent compound and higher affinity binding with the O-demethylated metabolite M1 to μ-opioid receptors. In animal products, M1 is up to 6 moments far more potent than tramadol in creating analgesia and 200 periods a lot more https://timj676anx7.newsbloger.com/profile