This examine proposes that K2's high adverse outcome event is owing, no less than partially, to unique JWH-018 metabolite action on the cannabinoid one receptor (CB1R), and implies that metabolites of most medicine, although not the carboxy metabolite, retain in vitro and in vivo activity at CB1Rs. Spice is unregulated https://eam220154208.blogtov.com/11595274/eam2201-no-further-a-mystery