Limb-threatening or important limb ischemia (CLI) is manifested by Continual (over two weeks) ischemic rest agony, ischemic wounds or tissue decline, or gangrene in one or both legs. Ischemic rest discomfort typically takes place shortly following slipping asleep; the patient is awakened by burning suffering or numbness during the forefoot. https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/